Prof. Illana Gozes

Dept. of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine

email: igozes@post.tau.ac.il

Research topic: Drug discovery and brain protection, microtubules – from gene to behavior, Alzheimer’s disease and related dementias, ALS and schizophrenia

Imaging projects in the lab include:

  • Immunofluorescence of nerve cells and nerve support cells – confocal microscopy.
  • In situ hybridization of embryonic zebra fish.
  • Correlation with small animal MRI imaging.   

SCMIC equipment used:

Confocal microscopy:  Zeiss 510 Meta – NLO (includes Two-photon LASER); Zeiss 410; Leica SP

Whole animal Imaging: Fluorescence Imaging – Cri Maestro; Bioluminescence Imaging – Photon Imager, Biospace; Fiber Confocal Microscopy – Cellvizio; Ultrasoun

Image analysis services: Deconvolution – Using the Huygens software; 3D and 4D Real-Time Interactive Image Visualization – Using the Imaris software

Figure: Protection against apoptosis and cytoskeletal disruption: By Dr. Ilona Zemlyak (Eur. J. Pharmacol. 618:9-14).

Key references (either using SCMIC equipment or have future plans to implement):

Zemlyak, I., Sapolsky, R. and Gozes, I. (2009) NAP protects against cytochrome c release: inhibition of the initiation of apoptosis. Eur. J. Pharmacol. 618:9-14.

Zemlyak, I., Manley, N., Vulih-Shultzman, I., Cutler, A.B., Graber, K., Sapolsky, R.M. and Gozes I. (2009) The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. J. Neurochem. 111:1252-1263.

Shiryaev, N., Jouroukhin, Y., Giladi, E., Polyzoidou, E., Grigoriadis, N.C., Rosenmann, H. and Gozes, I. (2009) NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. Neurobiol. Dis. 34:381-388.

Merenlender-Wagner, A., Pikman, R., Giladi, E., Andrieux, A. and Gozes, I. (2010) NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse–a microtubule-deficient model of schizophrenia. Peptides 31:1368-1373 (Olson Award Winner).

Shiryaev, N., Jouroukhin, Y. and Gozes, I. (2010) 3R tau expression modifies behavior in transgenic mice. J. Neurosci. Res. 88:2727-2735

Dresner, E., Agam, G. and Gozes, I. (2010) Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia. Eur Neuropsychopharmacol.

Shiryaev, N., Pickman, R., Giladi, E. and Gozes, I. (2011) Protection against tauopathy by the drug candidates NAP (Davunetide) and D-SAL: Biochemical, cellular and behavioral aspects. Curr. Pharm. Design. In Press.